50%+ of science journal articles have false conclusions

Via Boingboing:

In an article in the Public Library of Science Medicine, John P. A. Ioannidis, an epidemiologist, argues that more than 50 percent of the conclusions drawn in papers published in scientific journals are false. The money sentence is this one: "The replication process is more important than the first discovery." The popular culture version of science is about labcoats and discovery, the real world science is about publishing, review and replication.